The Group has entered into a number of research collaborations to develop new compounds with other pharmaceutical companies. The terms of these arrangements can include upfront fees, equity investments, loans and commitments to fund specified levels of research. In addition the Group will often agree to make further payments if future `milestones' are achieved. As some of these agreements relate to compounds in the early stages of development, milestone payments will continue for a number of years if the compounds move successfully through the development process. Generally the closer the product is to marketing approval the greater the possibility of success. The payments shown above represent the maximum that would be paid if all milestones are achieved. A number of commitments were made in 2004 under licensing and other agreements, principally with Theravance Inc., Tanabe Seiyaka Co. Ltd, Exelixis Inc. and Human Genome Sciences Inc. Pension commitments are provided in Note 35 to the Financial statements, `Employee costs'. Contingent liabilities The following table sets out contingent liabilities, comprising discounted bills, performance guarantees and other items arising in the normal course of business and when they are expected to expire.
6.10 The percentage of health care expenditure used for medicines, OECD.
Twentynine years ago, when I was first diagnosed When I finally informed my employer of my illness with Parkinson's, I took the diagnosis with a grain of I was sure they would find a reason to get rid of me. salt. I knew that something was wrong, but at the Actually they did everything they could to help me. ripe old age of thirty I had convinced myself that it Also, I worked with a great bunch of people who was just something that, given time, would pass. Of helped when they could. I worked 17 years after be course, as time flew by, people at work started ques ing diagnosed to the surprise of everyone but me. I tioning me about the way I was walking. My body "went for it." movements were changing. I couldn't see it because By the time I hit forty, there was no doubt that I the disease was progressing very slowly. But, never had a medical problem, and I found it was easier to theless, I was changing. I had always prided myself talk about it than to try to hide it. I've always won with the knowledge that I was in excellent physical dered why we try so very hard to hide Parkinson's condition. I worked very hard to stay that way. disease. We don't even want to discuss it in the be When I finally had to admit to myself that I did in ginning. It's not like we did anything wrong. It was deed have the disease, I still didn't want anyone to a real relief to finally be able to discuss it with peo know. All I knew for sure was that, although I had ple. the disease, it didn't have me. I lived with the deter I went to a few Parkinson's support groups, and de mined attitude, "I can beat it." cided they were not for me. All of the elderly people.
Scripps Center for Integrative Medicine, La Jolla, CA. * Dr. Bonakdar was the conference's Co-Director. Der Marderostan AH Beutler JA. The Review of Natural Products: The Most Complete Source of Natural Product Information [Facts and Comparisons] St. Louis, MO: Walters Kluwer Health, 2005.
Amount of home support services will allow palliative care patients to remain in their own homes in the last three months of their lives. Palliative care patients can now access about 200 hours of home-care services per month, for a total of 600 hours in the last three months of life. This represents an increase of about 50 hours per month. The increased entitlement will allow patients to access more concentrated home support services including nursing, personal care, home support, and respite support for families. There are no fees for enhanced palliative home-care services. In August 2006, Nova Scotia became one of the first provinces to move forward with an action plan that will help individuals suffering from chronic pain. The province will invest million annually to implement the plan. The major goal of the plan is to develop a seamless continuum of services that ensure Nova Scotians suffering from chronic pain receive equal access to quality, evidence-informed care. It also aims to ensure that all health professionals receive appropriate education to help them diagnose and treat their patients. The action plan establishes a chronic pain model that encompasses five key areas, specifically, self management, primary care education, enhanced community services, regional secondary services, and tertiary services.
Long-Term Complications 1. Nahas, A.M., Coles G.A. "Progressive Renal Failure." JR Coll Physicians Lond, 1997. 31 1 ; : 27-31. 2. "Effects of dietary protein restriction on the progression of moderate renal disease in the Modification of Diet in Renal Disease Study." J Soc Nephrol, 1996. 7 12 ; : 2616-26. 3. Campbell R., Ruggeneti, P., Remuzzi, G. "Halting the Progression of Chronic Nephropathy." J Soc Nephrol, 2002. 13: S190-S195. 4. Browning, D.J., Zhang, Z. "The effect of patient characteristics on response to focal laser treatment for diabetic macular edema." Opthalmology, 1997. 104 3 ; : 466-72. 5. Kotoula, M.G., Koukoulis, G.N., Zintzaras, E, et al., "Metabolic control of diabetes is associated with an improved response of diabetic retinopathy to panretinal photocoagulation." Diabetes Care, 2005. 28: 2454-2457 Keen, H., et al. "Treatment of diabetic neuropathy with gamma-linolenic acid." Diabetes Care, 1993. 16: 8-15. Okuda, Y., et al. "Long-term effects of eicosapentaenoic acid on diabetic peripheral neuropathy and serum lipids in patients with type II diabetes mellitus." J Diab Comp, 1996. 10: 280-287. Forst T., Pohlmann, T., Kunt T, et al. "The influence of local capsaicin treatment on small nerve fibre function and neurovascular control in symptomatic diabetic neuropathy. Acta Diabetol. 2002; 39: 1-6. Rodale Press, ed. Healing with Vitamins. Emmaus, PA: Rodale Press, 1996. 10. Reljanovic M., Reichel G., Rett K., et al. "Treatment of diabetic polyneuropathy with the antioxidant thioctic acid alpha-lipoic acid ; : a two year multicenter randomized double-blind placebo-controlled trial ALADIN II ; . Alpha Lipoic Acid in Diabetic Neuropathy. Free Radic Res. 1999; 31: 171-179. Hassaballa, H.A., et al. "The effect of continuous positive airway pressure on glucose control in diabetic patients with severe obstructive sleep apnea." Sleep Breath, 2005. 9: 176-180 and amantadine.
Antioxidants Glutathione, 250-500 mg per day Superoxide dismutase Zinc, 30 mg with 5 mg copper, with food. N-acetylcysteine NAC ; , 600 mg 3 times a day Vitamin C, 1000 mg 3 times a day. Vitamin E, 800 units 3 times a day. Alpha-lipoic acid, 250 mg 2 to three times a day.
Which case this dose would be 5000 mcg to 20, 000 mcg daily an excellent product is Cardiovascular Research's Megabiotin 7500 mcg per capsule; this company also sells its products under the brand name Ecological Formulas; take 2-3 capsules daily Choline 400-800 mg of choline citrate or 1000-3000 mg of phosphatidylcholine, 3 times per day Folic acid 1600 mcg, 3 times per day Gamma linolenic acid GLA ; 240 mg, 2-3 times per day; least expensive source is usually borage oil Inositol 500-2000 mg of myoinositol, three times per day Lecitihin one tablespoon, two or three times daily Magnesium 500-600 mg day with one meal per day may be useful; best to take magnesium separately from calcium as they compete for absorption Niacin 25-50 mg, 3 times per day Thiamine in the form of benfotiamine 600 mg daily; taken as four 150 mg capsules spread throughout the day ; . The Easiest and Least Expensive Nutrient Combination The simplest and least expensive way to obtain the above dosages is to start with an excellent multiple vitamin mineral formula. One I recommend is the potent multiple vitamin mineral called SuperBlend from SuperNutrition. [Note: if you cannot find the SuperNutrition SuperBlend locally, it is available at a discount from the Houston Buyers Club; see information below.] The SuperBlend contains appropriate starting levels of the B vitamins niacin, thiamine, folic acid, and B-6, as well as the associated factors choline and inositol, the magnesium, and the chromium. It would be necessary to add additional amounts of the two fatty acids alpha-lipoic acid and gamma-linolenic acid ; and the acetyl-L-carnitine since the amounts in the multiple are too low for neuropathy resolution. Aim for a total daily dosage in the above ranges. In addition, taking a tablespoon of lecithin two or three times daily would be very useful. Because of the success seen with its use in multiple trials, it also seems very important for diabetics to add the benfotiamine in the 600 mg dose listed above four 150 mg capsules daily, spread throughout the day ; . Its usefulness for HIV-associated neuropathy has not yet been studied so its possible effectiveness for this has not been shown in a clinical Lark Lands, 1985-2005 and amiloride.
It is with some misgivings but considerable enthusiasm that I assume the editorship of International Health News which has been so ably and professionally edited and published by Hans Larsen now for over 16 years. I will attempt to continue the traditions and philosophy Hans has established and endeavor to bring readers up-to-date and useful information derived from the peer-reviewed medical literature that directly relates to their health, both present and future. The emphasis will be on preventive medicine, the modifiable risk factors of prevalent diseases and disorders, the relationship between nutrition, lifestyle and health and finally health related news deemed of interest. Providing concise, reliable evidence-based information that will assist readers in maintaining a high quality state of health and wellbeing will continue to be the goal of this publication. There should be many fascinating and perhaps even sensational developments in both the areas of conventional and alternative medicine over the next few years and it is the aim of this newsletter to keep the readers abreast of these advances and provide information they can use. There will also continue to be book reviews and research reports, and I plan to have a special quarterly section on prostate problems. In this issue, several of the studies discussed involve diet or deal with issues such as the importance of omega-3 intake in the context of both heart disease and pain suppression and as well the risks of very high red meat consumption for premenopausal women. Diabetics should note the research results on oral alpha-lipoic acid for neuropathy. The News Briefs section contains a brief account of the use of pomegranate juice for slowing the progression of recurrent prostate cancer. This seemed important enough to include in the February issue rather than delay for inclusion in the upcoming quarterly review of prostate problems. Other news topics include the importance of a second opinion for breast cancer and the combined mortality risks of obesity and smoking. Finally, two book reviews are presented that should be of interest not only to diabetics but to anyone with even mildly abnormal blood glucose levels, especially those with metabolic syndrome and as well anyone looking for delicious low-carb recipes. Please bear in mind that the cost of publishing this newsletter is solely defrayed by income made from the online vitamin store. Without this, there would be no IHN. So, if you need to restock your supplements, please remember that by ordering through the on-line vitamin store you will be helping to maintain the web site and database, and the publication of IHN. You can find the store at : yourhealthbase vitamins . Wishing you continuing good health.
USA. Pharmacia, in conjunction with the US FDA, has issued a `Dear Healthcare Professional' and amiodarone.
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Mnire's syndrome may cause severely disabling and distressing vertigo. Typically patients present with a combination of vertigo, fluctuating low frequency hearing loss tinnitus and an aural pressure sensation. These symptoms may not necessarily occur simultaneously. Fortunately the majority of patients will respond to conservative medical management including a low salt diet and possibly diuretics. Vestibular sedatives and antiemetics may be useful for prolonged acute attacks. Short-term corticosteroids may be useful in refractory cases with relatively preserved hearing. More aggressive therapies such as intra-tympanic gentamicin and or surgery are reserved for refractory cases unresponsive to other measures and where there is significant hearing loss. Vestibular rehabilitation therapy may be useful in patients whose symptoms are stable.
Blood glucose levels are considered to be above normal when they rise above 120mg dl before meals or above 180 mg dl after meals. This happens to everyone with diabetes at certain times. However, if this happens often, it is a problem that needs attention. Very high blood glucose can cause serious problems in a short period of time and can even lead to death. Blood sugars above normal can lead to long term complications that affect the eyes, blood vessels, kidneys, and nerves. The following are common things that will cause blood glucose to rise. Food Emotional Stress Physical Stress being sick or in pain ; Getting less exercise than usual Not taking enough diabetes medicine Not taking the right diabetes medicine Extra glucose made by the liver Symptoms: Increased thirst Increased urination Increased fatigue Blurred vision and
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Underlying typical studies in this area is the notion that patient requests especially if triggered by direct-to-consumer advertising are often for mild or trivial ailments Weissman et al. 2004; Wilkes, Bell and Kravitz 2000 ; . Kravitz, et al. 2003 ; found that subjective health distress predicted requests for physician services referrals and prescriptions more powerfully than did an objective count of chronic conditions, leading them to conclude that "requests may be driven more by anxiety than disease burden" p. 1680 ; . To the best of our knowledge, no research exists that examines the effect of patient requests on sample-dispensing by the physician.
The importance of coq10, alpha-lipoic acid, and carnitine, however, lies in their ability to prevent age-related mitochondrial exhaustion and
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38. Anuradha CV et al. Taurine attenuates hypertension and improves insulin sensitivity in the fructose fed rat, and animal model of insulin resistance. Can J Physiol Pharm 77: 749-54, 1999. Nakaya Y et al. Taurine improves insulin sensitivity in the Otsuka Long-Evans fatty rat, a model of spontaneous type 2 diabetes. J Clin Nutr 71: 54-8, 2000. Kulakowski EC et al. Hypoglycemic properties of taurine: not mediated by enhanced insulin release. Biochem Pharm 33: 2835-8, 1994 Elizarova EP et al. First human ; experiments in taurine administration for diabetes mellitus: effects on erythrocyte membranes. Adv in Exp Med & Biol 403: 583-8, 1996. Hayes KC et al. Taurine modulates platelet aggregation in cats and humans. J Clin Nutr 49: 1211-6, 1989 Pop-Busui R et al. Depletion of taurine in experimental diabetic neuropathy; implications for nerve metabolic, vascular and functional deficits. Exp Neurol 168: 259-72, 2001. Obrosova IG et al. Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy. Exp Neurol 172: 211-19, 2001. Packer et al. Review: alpha lipoic acid as a biological antioxidant. Free Rad Biol Med 19: 227-50, 1995 Marangon K et al. Comparison of the effect of alpha-lipoic acid and alpha-tocopherol supplementation on measures of oxidative stress Free Rad Biol Med 27: 1114-21, 1999. Xu DP et al. Alpha lipoic acid dependent regeneration of ascorbic acid from dehydroascrobic acid in rat liver mitrochondria. J Bioenerg & Biomem 28: 77-85, 1996. Yaworsky K et al. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes. Diabetologia 43: 294-303, 2000 Estrada DE et al. Stimulation of glucose uptake by the natural coenzyme alpha lipoic acid. Diabetes 45: 1798-804, 1996. Zeigler D et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid : A 7 month multicenter randomized controlled trial. Diabetes Care 22: 1296-1301, 1999. Ziegler D et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid ALADIN Study ; . Diabetologia 38: 1425-33, 1995. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Rad Biol Med 27: 309-14, 1999 Konrad T et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care 22: 280-7, 1999. American Diabetes Association, Diabetes Creates Serious Cardiovascular Risk, In The News, 2002-06-17.
Lynn, It would seem to be that alpha lipoic acid is the one with the sulfur atoms attached, so that would be the one to take. The chemical structure of alpha-lipoic acid gives it very unique capabilities. It consists of a relatively small, eight-carbon atom chain having two attached sulfur atoms, one attached to the sixth carbon atom and the other sulfur atom attached to the eighth carbon atom, with the sulfur atoms also linked to each other. : healthy asp templates interview ?PageType Interview&ID 160 and endep.
MENIERE'S DISEASE Symptomatic Asymptomatic, adequate work up done to exclude more serious disease, with medical records Recent - 2 yrs since last attack . yrs since last attack 20 5 yrs & up since last attack Accept.
2. Objectives of Indian Public Health Standards IPHS ; for Primary Health Centres: The overall objective of IPHS is to provide health care that is quality oriented and sensitive to the needs of the community and caduet.
'' this was my biggest fear - that i might die on the table.
Complimentary newsletter from target health inc ; saturday, april 4, 1998 new readers back to top this week we would like to welcome guy lander rosenman & colin, llp ; and yogesh patel target health and ascorbic.
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The mission of the Heart and Stroke Foundation of Canada HSFC ; is to reduce death and disability from heart disease and stroke. So then why is obesity one of its top strategic priorities? Being overweight or obese is a leading risk factor for heart disease and stroke. Twenty-six per cent of children and adolescents aged two to 17, and 60 per cent of adults in Canada are overweight or obese. That's why the Foundation is focusing on obesity - through research, advocacy, and health information. Explains CEO Sally Brown, "If we don't deal with the obesity epidemic, we are taking a step backwards in preventing cardiovascular CVD ; research investment and created a strategic envelope of money specifically to partner with the CIHR Institutes." She says although they initially assumed that most of HSFC's collaborative work would be undertaken with the Institute of Circulatory and Respiratory Health, INMD soon also became a key partner. The Foundation's decision to make obesity a strategic priority meshed perfectly with INMD's decision to focus on this area. "I have to take my hat off to the leadership provided by Diane Finegood. I think it was very brave of her to choose such a clear and decisive focus for the research that INMD would fund over the next while, because if you make a choice to invest in one area you know you're going to been seen as focusing less on other areas. That's hard. But because of that decision, I think the Institute will have real impact." The first partnership between HSFC and INMD in 2002 included the Canadian Diabetes Association, The Kidney Foundation of Canada and CIHR's Institute of Circulatory and Respiratory Health. Together these organizations developed a Chronic Disease New Emerging Team grant program, and ultimately funded six research teams over five years. Two years later, HSFC approached INMD with a proposition to work together to offer personnel awards to build capacity for obesity research. HSFC lead the endeavour organizing partners, drafting the Request for Applications, and organizing the peer review process. Brown was happy with the outcome. "We awarded 15 personnel awards collectively through the Target Obesity program. We're very pleased with that." HSFC and INMD went on to collaborate to support four Obesity New Emerging Teams through two consecutive competitions and then seven operating grants specific to childhood obesity and chlorthalidone and alpha-lipoic.
The mean pharmacodynamie parameter estirnates for SBP. DBP. HR and MAP are listed.
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Attendees: Rob Colburn, Christina Daniels, Darin Elliott, Kevin Green, Rhonda Harden, Clemice Hurst, Jimmy Jackson, Tiffany Minnifield, Bernie Olin, Steven Rostand, Kevin Royal, John Searcy, Paula Thompson, Jerome Harrison Absent: Kelli Littlejohn Rob Colburn, chair, called the meeting to order at 1: 00pm. Review and Adoption of Minutes of April 26, 2006 meeting: Rob Colburn asked if there were any additions, deletions or changes to the minutes of the April 26, 2006 meeting. No changes or additions were brought to the attention of the Board. Rob asked for a motion to approve the minutes as presented. Paula Thompson so moved and Jimmy Jackson seconded. The motion passed by a voice vote with no audible dissenters. The minutes were adopted as written. DUR Update: Christina Daniels began the DUR Update by reviewing reports for the months of March, 2006; April, 2006; and May, 2006. For the month of March, Christina noted that there were 13, 791 manual PA requests and 13, 770 electronic PA requests. She noted that the sum of those two numbers does not equal the grand total of requests for PAs and overrides. She explained that in the first report, HID is only considering non-duplicate electronic requests. This does change the numbers slightly. Also in March, it was noted that two requests for acne products were approved. Although Alabama Medicaid does not cover acne medications, two requests for Amnesteem were approved by the Medical Director; both for a patient with a diagnosis of malignant neuroblastoma. Christina then reviewed the Monthly Help Desk Report, PA and Override Response Time Ratio Report and noted that HID was within the time requirements for the month of March. She discussed the Top 25 Drugs Based on Number of Claims and also the Top 25 Drugs Based on Claims Cost. She also reviewed the Top 15 Therapeutic Classes by Total Cost of Claims. For the months of April and May, although the Synagis season had ended, HID received nine requests for Synagis. All were retroactive requests for dates of service within the official Synagis season and were appropriately approved according to guidelines. Christina then reviewed the Monthly Help Desk Report, PA and Override Response Time Ratio Report, the Top 25 Drugs, and the Top 15 Therapeutic Classes for the months of April and May. Quarterly Reports: Christina reviewed the Program Summary. She reviewed the three month assessments for the October 1 through December 31, 2005 and the January 1 through March 31 time periods. She noted a prescription claims cost of 2, 997, 850.69 and an average paid per recipient per month of 3.56 in the October 1 through December 31 time period. Comparatively, for the January 1, 2006, through March 31, 2006, time period she noted a prescription claims cost of , 284, 681.30 and an average paid per recipient per month of 4.85. She noted that the decrease in the average paid per prescription per month is due to the.
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Per year with only two years of no crossings. But what has happened the past year is startling. This past year, 2005, there were six of our members who met the challenge. Prior to 2005, three swimmers in any one year was the record. As mentioned at the banquet, we should never view crossing a channel as some common ritual that must be done to qualify for credibility as a distance swimmer. It so much more in the amount focus, energy, and yes, money and bravery that one has to expend in order to do such an epic, physical event. And Kudos also have to go to the family and friends who give so much in the way of support that is so necessary to the swimmer's success. There have been so many of you who willingly swam miles and miles alongside our channel contenders. The grand prize has to go to Jerry Anderson, who swam so many miles that he could have jumped into either channel and made it across. Great job, Jerry!!! Here are the six swimmers who mastered the channel this past year Andy and Will did side by side on the same day ; : Andy Hewitt Will Newbern Phil Garn David Cooper Bill Hoehn Rick Knepper No other swim club in the world has near the amount of Catalina solo swimmers as our club, but we modestly put this forth as fact.never to flaunt or brag. The same pattern is happening in the English Channel. During the past two years, we have had three swimmers cross each year. At total of 19 San Diegans have crossed the "Mother of all Channels" since Florence Chadwick did it three times in 1951, 1953, and 1955. This year the three that braved the unpredictable whims of the English Channel are: Tom Hecker Andy Hewitt Tim Cheesman Tim was attempting a double, but the seas were buffeted by force 5 winds and he had to abandon this goal. The solo one way crossing, however, was mastered. Andy Hewitt, a Marine Lt. Colonel, is most amazing in that he swam both the Catalina and English Channels as well as running a marathon after his return from an Iraq tour of duty last Spring. He found a way to stay fit in the compound not swimming of course ; but by running and physical training. And by the end of summer, Andy prevailed. Marc Lewis, Claudia Rose and Chris continued on pg. 8.
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References 1. Nickander KK, Schmelzer JD, Rohwer DA, and Low PA. Effect of alpha-tocopherol deficiency on indices of oxidative stress in normal and diabetic peripheral nerve. J Neurol Sci. Oct 1994. 126 1 ; : 6-14. 2. Marenzi G, Assanelli E, Marana I, et al. N-acetylcysteine and contrast-induced nephropathy in primary angioplasty. N Engl J Med. 2006. 354: 2773-2782. Yu JX, Yin XX, Shen JP Qiu J, Yin HL, and Jiang SJ. Protective effects of ben, dazac lysine on diabetic peripheral neuropathy in streptozotocin-induced diabetic rats. Clin Exp Pharmacol Physiol. Dec 2006. 33 12 ; : 1231-1238. 4. The effects of treatment with alpha-lipoic acid or evening primrose oil on vascular hemostatic and lipid risk factors, blood flow, and peripheral nerve conduction in the streptozotocin-diabetic rat. Metabolism. Aug 2001. 50 8 ; : 868-875. 5. Polyol pathway hyperactivity is closely related to carnitine deficiency in the pathogenesis of diabetic neuropathy of streptozotocin-diabetic rats. J Pharmacol Exp Ther. Dec 1998. 287 3 ; : 897-902. 6. Effect of sorbinil and ascorbic acid on myo-inositol transport in cultured rat Schwann cells exposed to elevated extracellular glucose. J Neurochem. Nov 1997. 69 5 ; : 2011-2018. 7. Meister A. Glutathione, ascorbate, and cellular protection. Cancer Res. 1994. 54: 1969S-1975S. Kidd PM. Glutathione: systemic protectant against oxidative and free radical damage. Altern Med Rev. 1997. 1: 155-176. Weber GF. Final common pathways in neurodegenerative diseases: regulatory role of the glutathione cycle. Neurosci Biobehav Rev. 1999. 23: 1079-1086. Vijayalingam S, Parthiban A, Shanmugasundaram KR, et al. Abnormal antioxidant status in impaired glucose tolerance and non-insulin-dependent diabetes mellitus. Diab Med. 1996. 13: 715-719 Diabetologia. Springer Verlag. Prepared for publication.
CARDIAC CHANGES IN EXPERIMENTAL SEPSIS 155 M. Rubia Nunes Celes, D.T Duenas, J.C Alves-Filho, F.Q Cunha, M.A Rossi Faculty of Medicine of Ribeirao Preto, Ribeirao Preto, SP, Brazil ALPHA-LIPOIC ACID AMELIORATES DOXORUBICIN-INDUCED MYOCARDIAL TOXICITY A.A Al-Majed, A.M Gado, O.A Al-Shabanah, M.A Mansour College of Pharmacy, King Saud University, Saudi Arabia 156.
